Wife drives a Lexus ES 330 (Camry with heavy makeup) bought new 9 years ago,reliable and comfy......
has been a great vehicle....knock on wood 
Funny drove home an ES 330 this evening.
OK didn't buy it technically. They made up some reason to need to keep our trade in to 'see if their buyer would give a better deal' or some such so we got to 'borrow' the ES 330 overnight. Once again i'm sure a sales gimmick to make you loooove the car after you've driven home in it. Whatever. Wasn't going to sign without research or seeing the car in daylight.
On the plus side man this thing is cherry. Every possible upgrade you could think of. Seat warmers, seat coolers.. navigation system, 6-disc CD changer, adjustable everything.. even has this button you push to make a sun screen pop out the back for the back window. It's insane.
Downside.. the damned stereo doesn't play mp3s which kinda pisses me off. My scion is the same year and it does despite having power virtually nothing. Oh well, i'm kinda off mp3s of recent anyway and the 6 disc changer is probably enough but still kinda wtf given everything else. Stereo does sound amazing though. We also test drove a Q35 tonight same year.. man the lexus eats the car's lunch. Makes it look like a total POS at least on the amenities side of things.
The car is also a bit big, i'd prefer something sportier but given how the IS 250 only
looks sporty and actually isn't i think the power of the ES 330 will be better than a car that looks faster but isn't. The IS300 is funner but older and more dogged out in most cases at this point.
Yosho also recommended the GS 300 line and the LS line. The LS line is nice but seems pricy. I admit the GS looks a lot nicer but i think its out of my price range as would either need to drop down to a 2002 or 2003 or step up to 100k+ miles which i'm not sure is worth it to me.. i think the ES 330 will be nice enough but depends on what kinda deal we arrive at tomorrow.